The relationship between cleft lip and palate children with their trace elements in serum

Objective: To study the relationship between Cleft lip and palate children with their trace elements in serum. Methods: All patients were divided into four groups. The first group of unilateral cleft lip was constituted with 72 patients. Accordance with the ratio 1:2 random survey, it selected the health children for control group. It detected the trace elements in serum by collecting 2-3 mL Fasting venous blood. Made determination of vitamin content in high performance liquid chromatography and detection of respiratory infection history by indirect immunoinfluscent assays for nine kinds of antibody for different pathogens. Then it analyzed the data by SPSS; Results: The incidence of disease children concentrated on the Genetic Factors and the Mining Area children (P<0.05). As for the zinc content, it was at lower level in every disease group compared with the control group. Selenium content was at considerable level between unilateral cleft lip groups with control group. However, other disease groups were at lower level. Used Chi-square test, it indicated that the changes of the three key trace elements could be Synergistic effect with Adenoviruses and respiratory syncytial virus infection; Conclusion: The differences of crucial trace elements (including: zinc, selenium, copper and vitamin A) in children’s serum could have close relationship with inborn cleft lip and palate disease.